Specifications

Variant Details
Catalog IDR32738Supplier Catalog IDR32738
Size100 µgPrice N/A
Supplier N/A Package Content 100 µg of antibody
General
ClonalityPolyclonalHostRabbit
ReactivityHuman, Mouse, RatApplicationsWestern Blot
ConjugatedUnconjugatedIsotypeIgG
ImmunogenAmino acids Q4-Q213 from the human protein were used as the immunogen for the HDAC4 antibody.DilutionWestern blot: 0.5-1µg/ml
Purification MethodAntigen affinityUniProtKBP56524
Additional InformationOptimal dilution of the HDAC4 antibody should be determined by the researcher.Shipping Temperature4 °C
Storage & Handling4 °CStorage BufferNone
Shelf Life12 monthsPurityAntigen affinity

Description

Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene. It is mapped to 2q37.3. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

For research use only.

Resources

Protocol

Protocol: HDAC4 Antibody

HDAC4 Antibody (R32738)

HDAC4 Antibody (R32738)

Article

Protocol

Protocol: HDAC4 Antibody

HDAC4 Antibody (R32738)

HDAC4 Antibody (R32738)

Safety

Brochure

Handbook

Publication

Validation